Pyrimethamine CAS 58-14-0

Product Name: Pyrimethamine
Synonyms: 2,4-Diamino-5-(4-chlorophenyl)-6-ethylpyrimidine;2,4-Diamino-5-chlorophenyl-6-ethylpyrimidine;2,4-Pyrimidinediamine, 5-(4-chlorophenyl)-6-ethyl-;2,4-Pyrimidinediamine, 5-(p-chlorophenyl)-6-ethyl-;2,4-Pyrimidinediamine,5-(4-chlorophenyl)-6-ethyl-;4753 R.P.;4753r.p.;5-(4`-chlorophenyl)-2,4-diamino-6-ethylpyrimidine
CAS: 58-14-0
MF: C12H13ClN4
MW: 248.71
EINECS: 200-364-2
Product Categories: -;APIs & Intermediate;Pyrimidine;Organics;Amines;Bases & Related Reagents;Heterocycles;Intermediates & Fine Chemicals;Nucleotides;Pharmaceuticals;Inhibitor;Heterocycle-Pyrimidine series;DARAPRIM
Mol File: 58-14-0.mol
Pyrimethamine Structure
Pyrimethamine Chemical Properties
Melting point 233-234°C
Boiling point 393.35°C (rough estimate)
density 1.2171 (rough estimate)
refractive index 1.6110 (estimate)
storage temp. 0-6°C
solubility Prepare the solution immediately before use. Dissolve 0.25 g in a mixture of 1 volume of methanol R and 3 volumes of methylene chloride R and dilute to 10 mL with the same mixture of solvents. The solution is clear (2.2.1) and not more intensely coloured than reference solution BY6 (2.2.2, Method II).
form neat
pka pKa 7(t=20.0) (Uncertain)
Water Solubility <0.01 g/100 mL at 21 ºC
λmax 276nm(lit.)
Merck 14,7985
BRN 219864
Stability: Stable, but light sensitive. Combustible. Incompatible with strong oxidizing agents.
CAS DataBase Reference 58-14-0(CAS DataBase Reference)
NIST Chemistry Reference Pyrimethamine(58-14-0)
EPA Substance Registry System 2,4-Pyrimidinediamine, 5-(4-chlorophenyl)-6-ethyl- (58-14-0)
Safety Information
Hazard Codes Xn
Risk Statements 22-36
Safety Statements 26
RIDADR 3249
WGK Germany 3
RTECS UV8140000
HazardClass 6.1(b)
PackingGroup III
HS Code 29335990